2-Phenylglycine → HCID 18941964, Verbindung

HRID 355329

Reaktionsgleichung

Reaktionsgleichung von HRID 355329
[CH2:1]([O:8][CH2:9][C:10](Cl)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:13]1[CH:18]=[CH:17][C:16]([CH:19]([NH2:23])[C:20]([OH:22])=[O:21])=[CH:15][CH:14]=1.[OH-].[Na+]>O>[C:2]1([CH2:1][O:8][CH2:9][C:10]([NH:23][CH:19]([C:16]2[CH:17]=[CH:18][CH:13]=[CH:14][CH:15]=2)[C:20]([OH:22])=[O:21])=[O:11])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 38662-PhenylglycineHCID 14798Sodium Hydroxide2×HCID 177085Benzyloxyacetyl chloride

Produkt 1

HCID 18941964HCID 18941964, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Benzyloxyacetyl chloride (6.3 mL, 40 mmol) is added to a solution of DL-phenylglycine (3.00 g, 19.8 mmol) and NaOH (2.32 g, 58.0 mmol) in 100 mL H2O and allowed to stir overnight. The reaction pH is adjusted to 11 with 3M NaOH 5 and washed with (3×50 mL) Et2O, then brought to pH=3 with concentrated HCl. The resulting precipitate is collected, washed with H2O and dried to obtain the title compound as an off-white solid. mp 127°-30° C.

Aufarbeitung

  1. washwashed with (3×50 mL) Et2O
  2. customThe resulting precipitate is collected
  3. washwashed with H2O
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8eccc72f10f7460caaf37e27756ef51f
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05830869

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