Nilutamide → 5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione

HRID 355587

Reaktionsgleichung

[F:1][C:2]([F:22])([F:21])[C:3]1[CH:4]=[C:5]([N:12]2[C:16](=[O:17])[C:15]([CH3:19])([CH3:18])[NH:14][C:13]2=[O:20])[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[H-].[Na+].Br[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[CH3:18][C:15]1([CH3:19])[N:14]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[C:13](=[O:20])[N:12]([C:5]2[CH:6]=[CH:7][C:8]([N+:9]([O-:11])=[O:10])=[C:3]([C:2]([F:1])([F:21])[F:22])[CH:4]=2)[C:16]1=[O:17]

Komponenten

Edukt 3

HCID 4493Nilutamide

HCID 127421-Bromononane

HCID 24758Sodium hydride

Produkt 1

HCID 221169515,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione

Versuchsvorschrift

Using the procedure of Example 1, 1 g of 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione prepared from a 50% suspension of 170 mg of sodium hydride in oil and 0.7 ml of 1-bromononane were reacted to obtain after chromatography on silica 1.08 g of the desired product melting at 63° C.

Aufarbeitung

customwere reacted

Quellen und Nachweise

ORD-Eintrag: ord-16d7ce72b41647a28ab842708b64cc3d
Quelldatensatz: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: USRE035956

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