Formaldehyde → Ethyl 2-(5-phenylthiazolidin-4-on-3-yl)isobutyrate

Triethylamine (3 g) was added to a suspension of ethyl 2-aminoisobutyrate hydrochloride (5 g) in toluene (60 mL) at room temperature. 2-Mercaptophenylacetic acid (6.44 g) was added to the mixture, which was then stirred at room temperature. After 10 minutes, a 35% formaldehyde aqueous solution (2.61 g) was added dropwise to the mixture. After the addition was completed, a catalytic amount of p-toluenesulfonic acid was added, and the mixture was allowed to react under heating at reflux for 4 hours, while water generated was excluded by azeotropic distillation from the reaction system. The reaction mixture was cooled to room temperature, to which ethyl acetate was added, and was then washed with a saturated sodium hydrogencarbonate aqueous solution and a saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The solvent was distilled under reduced pressure to give 5.49 g of the title compound as viscous oil.

1. additionAfter the addition
2. customto react
3. temperatureunder heating
4. distillationgenerated was excluded by azeotropic distillation from the reaction system
5. temperatureThe reaction mixture was cooled to room temperature, to which ethyl acetate
6. additionwas added
7. washwas then washed with a saturated sodium hydrogencarbonate aqueous solution
8. dry with materiala saturated aqueous sodium chloride and dried over anhydrous sodium sulfate
9. distillationThe solvent was distilled under reduced pressure

ORD-Eintrag

ord-1dba1b63eb9a4834be0247feb505f5fe

Quelldatensatz

uspto-grants-1998_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05834401