Reaktionsgleichung
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=2)[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.OC1C=C(C=CC=1)CN1CCCCC1.BrCCCC(OCC)=O.[OH-].[K+].Cl>O>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=2)[O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Komponenten
Edukt 5
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In a similar manner to that described above in Example 17 ethyl 4-(3-piperidinomethylphenoxy)butyrate (b.p. 190°-200° C./0.005 mm Hg) was prepared from N-3-hydroxybenzylpiperidine and ethyl 4-bromobutyrate. The resulting ester (21.4 g) was then hydrolysed by heating under reflux with potassium hydroxide (3.6 g), water (210 ml) and industrial methylated spirit (210 ml) for 30 minutes. 5N Hydrochloric acid (13.7 ml) was then added and the solvent removed by evaporation in vacuo. The residue was dried by azeotropic distillation with toluene and then with ethanol. The residue was digested with ethanol (420 ml). The ethanolic liquor was filtered and the solvent removed from the filtrate to give a yellow oil which was crystallised from a mixture of methanol and ether to give 4-(3-piperidinomethylphenoxy)butyric acid (m.p. 73°-77° C.).
Aufarbeitung
- temperaturehydrolysed by heating
- customthe solvent removed by evaporation in vacuo
- dry with materialThe residue was dried by azeotropic distillation with toluene
- filtrationThe ethanolic liquor was filtered
- customthe solvent removed from the filtrate
- customto give a yellow oil which
- customwas crystallised from a mixture of methanol and ether
Quellen und Nachweise
- ORD-Eintrag
- ord-f2f7774fd70e4e219964cafbfdaf085e
- Quelldatensatz
- uspto-grants-1988_08
- Patentnummer
- US04767769
Verknüpfte Notizen
Wird geladen…