2-Methylamino-3-nitro-6-phenylthiopyridine → 3-Amino-2-methylamino-6-phenylthiopyridine

HRID 356323Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 356323
[CH3:1][NH:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][CH:6]=[C:5]([S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1>CO.[Pd]>[NH2:9][C:8]1[C:3]([NH:2][CH3:1])=[N:4][C:5]([S:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 107301262-Methylamino-3-nitro-6-phenylthiopyridine

Produkt 1

HCID 105137093-Amino-2-methylamino-6-phenylthiopyridineAusbeute 83,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A procedure similar to that described in Example 6, was repeated, except that 5.40 g of 2-methylamino-3-nitro-6-phenylthiopyridine (prepared as described in Preparation 88) were hydrogenated in 80 ml of methanol in the presence of 1.10 g of 10 % w/w palladium-on-charcoal. After working up the product as described in Example 6, 4.00 g of the title compound having Rf=0.69 (on silica gel thin layer chromatography using ethyl acetate as the developing solvent) were obtained.

Quellen und Nachweise

ORD-Eintrag
ord-f33a9763eaf148adaa6b5d91fa91622f
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05834501

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