Hexane → 2-Amino-3-hydroxybenzonitrile

HRID 357292

Reaktionsgleichung

Reaktionsgleichung von HRID 357292
[N+:1]([C:4]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-])=O.[H][H].CCCCCC.C(OCC)(=O)C>[Pd].C(O)C>[NH2:1][C:4]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

Komponenten

7

Edukt 4

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 138624233-Hydroxy-2-nitrobenzonitrileHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 159063362-Amino-3-hydroxybenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A parr bottle was charged with palladium on activated carbon (5%, 0.196g). A solution of 2-nitro-3-hydroxybenzonitrile (1.31 g, 0.008 mol) in 40 ml of ethanol was added. The reaction mixture was placed under 25 psi of hydrogen gas and shaken for 1 hour. TLC (1:1 hexane:ethyl acetate) shows that no starting material remained. The mixture was filtered through Celite® and evaporated to yield 2-amino-3-hydroxybenzonitrile, 1.01 g (0.0075 mol, 94%).

Aufarbeitung

  1. filtrationThe mixture was filtered through Celite®
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-59f4430508a249a3b05078ccf53bc50f
Quelldatensatz
uspto-grants-1998_11
Patentnummer
US05840764

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