2-chlorothiophene-3-carboxylic Acid → 5-Bromo-2-chlorothiophene-3-carboxylic acid
Reaktionsgleichung
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([OH:9])=[O:8].C1C=C[NH+]=CC=1.[Br:16][Br-]Br>C(O)(=O)C>[Br:16][C:4]1[S:3][C:2]([Cl:1])=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
A mixture of 2-chloro-3-thiophenecarboxylic acid (2.44 g), pyridinium bromide perbromide (5.33 g) and acetic acid (15 ml) was stirred at 40° C. for 4 hours and poured into ice-water. Precipitated crystals were collected by filtration, dissolved in ethyl acetate and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give 5-bromo-2-chloro-3-thiophenecarboxylic acid (2.81 g) as crystals.
Aufarbeitung
- customPrecipitated crystals
- filtrationwere collected by filtration
- dissolutiondissolved in ethyl acetate
- dry with materialdried over anhydrous magnesium sulfate
- concentrationThe solution was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-572152529d804ea3aea13e865119883c
- Quelldatensatz
- uspto-grants-1998_11
- Patentnummer
- US05840917
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