Water → 1,4-Dioxaspiro(4.5)decan-8-ol

HRID 358352

Reaktionsgleichung

Reaktionsgleichung von HRID 358352
[OH:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[OH2:9].[C:10]1([CH3:20])C=CC(S(O)(=O)=O)=CC=1.O>C1C=CC=CC=1>[OH:8][CH:5]1[CH2:6][CH2:7][C:2]2([O:9][CH2:10][CH2:20][O:1]2)[CH2:3][CH2:4]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 521998p-Toluenesulfonic acid monohydrateHCID 5437064-Hydroxycyclohexanone

Produkt 1

HCID 5673521,4-Dioxaspiro(4.5)decan-8-olAusbeute 33.478,602 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 4hydroxycyclohexanone (228 g, 2.0 mol) ethylene glycol (124 g, 2.0 mol) and p-toluenesulfonic acid monohydrate (0.89 g) in 2.0 l of benzene was stirred at reflux in a 3-l, three-necked, round-bottomed flask equipped with a Dean-Stark trap. The mixture was refluxed until the required amount of water had been removed. Solvent was removed by distillation and the residue was fractionally distilled at 85°-88.5° C. (0.08 mm Hg.) to give 247.8 g of the sub-titled intermediate. (78%), Lit bp 90°-95° C. (0.2 mm Hg.). (M. K. Batuev, et al., Ixvest. Akad. Nauk S.S.S.R., Otdel, Khim Nauk, 1960, 538-549.) IR, OH (3420), C--O (1105, 1035, 920); Mass Spectrum, m/e 158 (M+).

Aufarbeitung

  1. customthree-necked, round-bottomed flask equipped with a Dean-Stark trap
  2. customhad been removed
  3. customSolvent was removed by distillation
  4. distillationthe residue was fractionally distilled at 85°-88.5° C. (0.08 mm Hg.)

Quellen und Nachweise

ORD-Eintrag
ord-fea77cbe1875419f90b081b4129daca4
Quelldatensatz
uspto-grants-1984_08
Patentnummer
US04466977

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