Water → 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinylcarbony]-3,4-dihydrocarbostyril

HRID 358502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 358502
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=O.C1(=O)NC(=O)CC1.[N:21]1([C:27]([C:29]2[CH:30]=[C:31]3[C:36](=[CH:37][CH:38]=2)[NH:35][C:34](=[O:39])[CH2:33][CH2:32]3)=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.O>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([N:24]1[CH2:25][CH2:26][N:21]([C:27]([C:29]2[CH:30]=[C:31]3[C:36](=[CH:37][CH:38]=2)[NH:35][C:34](=[O:39])[CH2:33][CH2:32]3)=[O:28])[CH2:22][CH2:23]1)=[O:8]

Komponenten

5

Edukt 3

HCID 962WaterHCID 131953426-(Piperazine-1-carbonyl)-3,4-dihydroquinolin-2(1H)-oneHCID 20435645Succinimide 3,4-dimethoxybenzoate

Produkt 1

HCID 131953576-[4-(3,4-Dimethoxybenzoyl)-1-piperazinylcarbony]-3,4-dihydrocarbostyril

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

123 Grams of succinimide 3,4-dimethoxybenzoate and 137 mg of 6-(1-piperazinylcarbonyl)-3,4-dihydrocarbostyril were dissolved in 2 ml of dimethylformamide and stirred for 24 hours. The water was added to the reaction mixture and extracted with chloroform, the chloroform extract was washed with water and a saturated sodium chloride aqueous solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation and the residue was recrystallized from ethanol-chloroform to obtain 100 mg of 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinylcarbonyl]-3,4-dihydrocarbostyril. Colorless granular crystals. Melting point: 238°-239.5° C.

Aufarbeitung

  1. extractionextracted with chloroform
  2. extractionthe chloroform extract
  3. washwas washed with water
  4. dry with materiala saturated sodium chloride aqueous solution and dried with anhydrous sodium sulfate
  5. customThe solvent was removed by distillation
  6. customthe residue was recrystallized from ethanol-chloroform

Quellen und Nachweise

ORD-Eintrag
ord-cc994ebd672c4949aabcbd159c27bb07
Quelldatensatz
uspto-grants-1984_08
Patentnummer
US04468402

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