Dichloromethane → N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)-3-chlorophenyl]-2,4-dichlorobenzamide

Reaktionsgleichung

[N:1]1[N:10]2[C:4]([CH2:5][NH:6][C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9]2)=[CH:3][CH:2]=1.[Cl:15][C:16]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:17]=1[C:18]([NH:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1)=[O:19].C(N(C(C)C)CC)(C)C.[Cl:44]CCl>>[N:1]1[N:10]2[C:4]([CH2:5][N:6]([C:25]([C:24]3[CH:28]=[CH:29][C:21]([NH:20][C:18](=[O:19])[C:17]4[CH:30]=[CH:31][C:32]([Cl:34])=[CH:33][C:16]=4[Cl:15])=[CH:22][C:23]=3[Cl:44])=[O:26])[C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH2:9]2)=[CH:3][CH:2]=1

Komponenten

Edukt 4

HCID 6344Dichloromethane

HCID 81531Diisopropylethylamine

HCID 116023454-[(2,4-dichlorobenzoyl)amino]benzoyl Chloride

HCID 130628255,10-dihydro-4H-pyrazolo[5,1-c][1,4]benzodiazepine

Produkt 1

HCID 21836980N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)-3-chlorophenyl]-2,4-dichlorobenzamide

Versuchsvorschrift

As described for Example 518, a mixture of 0.185 g of 5,10-dihydro-4H-pyrazolo[5,1-c][1,4]benzodiazepine, 0.472 g of 4-[(2,4-dichlorobenzoyl)amino]benzoyl chloride and 0.158 g of diisopropylethylamine in 10 ml of dichloromethane is stirred at room temperature overnight to give the product (0.27 g) as a pale yellow glass; anal. calc'd: C, 58.7; H, 3.4; N, 11.0; Cl, 20.8 Found C, 57.3; H, 3.3; N, 9.5; Cl, 21.3.

Quellen und Nachweise

ORD-Eintrag: ord-7652de077fa448338717e7eedac5a806
Quelldatensatz: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05733905

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