Dimethylformamide → 4-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide

HRID 359032

Reaktionsgleichung

Reaktionsgleichung von HRID 359032
[C:1]1([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+]([NH:25][C:26](N)=[O:27])([O-])=O.CN(C)C=O>O>[C:1]1([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([N:16]3[CH2:21][CH2:20][N:19]([C:26]([NH2:25])=[O:27])[CH2:18][CH2:17]3)=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 62372NitroureaHCID 97956441-phenyl-3-(1-piperazinyl)-1H-indazole

Produkt 1

HCID 151170994-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamideAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4.9 g of 1-phenyl-3-(1-piperazinyl)-1H-indazole, 5.1 g of nitrourea, and 80 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized from ethyl acetate (2×) to yield 3.1 g (57%) of 4-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide, m.p. 151°-153°.

Aufarbeitung

  1. temperaturewas heated on a steam bath for 15 minutes
  2. customthe resulting precipitate was recrystallized from ethyl acetate (2×)

Quellen und Nachweise

ORD-Eintrag
ord-e75dcb048f51472e84f9ab3bd0a92f90
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US04999356

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