Acetonitrile → 1-(2-Fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidine

HRID 359506Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 359506
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Br)=[CH:4][N:3]=1.[N+:10]([N:13]=[C:14]1[NH:18][CH2:17][CH2:16][NH:15]1)([O-:12])=[O:11].C(=O)([O-])[O-].[K+].[K+].C(#N)C>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:15]2[CH2:16][CH2:17][NH:18][C:14]2=[N:13][N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1

Komponenten

6

Edukt 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 220506385-(Bromomethyl)-2-fluoropyridineHCID 135413413N-nitroimidazolidin-2-imine

Produkt 1

HCID 1363427881-(2-Fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidineAusbeute 50,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2-fluoro-5-pyridylmethyl bromide (9.5 g), 2-(nitroimino)imidazolidine (6.5 g), potassium carbonate (7.6 g) and acetonitrile (100 ml) was refluxed for 2 hours with stirring. After the reaction, the reaction mixture was cooled to room temperature, and cold water (100 ml) was added. The resulting crystals were collected by filtration and washed with ether to give slightly colored 1-(2-fluoro-5-pyridylmethyl) 2-(nitroimino)imidazolidine (6.0 g) as the desired compound.

Aufarbeitung

  1. temperaturewas refluxed for 2 hours
  2. customAfter the reaction
  3. filtrationThe resulting crystals were collected by filtration
  4. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-8f03afa67c5c4f73a53c530329a84329
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US05001138

Notizen zur Reaktion

Wird geladen…