Indole-3-pyruvic acid → HCID 54134943, Verbindung

HRID 359727

Reaktionsgleichung

Reaktionsgleichung von HRID 359727
C[N-]C.[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH2:13][C:14](=[O:18])[C:15]([OH:17])=O)=[CH:5]1.[CH:19]1[CH:20]=[CH:21][C:22]2N(O)N=[N:25][C:23]=2[CH:24]=1.C1(N)CCCCC1.CN1CCOCC1>CCN=C=NCCCN(C)C.Cl>[CH:23]1([NH:25][C:15](=[O:17])[C:14]([CH2:13][C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:4][CH:5]=2)=[O:18])[CH2:24][CH2:19][CH2:20][CH2:21][CH2:22]1

Komponenten

7

Edukt 5

HCID 803Indole-3-pyruvic acidHCID 7965CyclohexylamineHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 182180Dimethylazanide

Produkt 1

HCID 54134943HCID 54134943, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideLösungsmittel

Versuchsvorschrift

The same method as described in Example 7 was followed for the preparation of N,N-dimethylamide. 500 mg 3-indolepyruvic acid were reacted with 400 ml HOBt and 570 ml EDC.HCl. 340 microliters of freshly distilled cyclohexylamine and 325 microliters NMM were added to the solution, which was reacted for 5 hours.

Aufarbeitung

  1. customwas reacted for 5 hours

Quellen und Nachweise

ORD-Eintrag
ord-ab4f0216453f46f89472cb195305881f
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US05002963

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