Hydrochloric Acid → 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

HRID 359831Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 359831
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[CH:7][CH:8]=1.[CH3:11][C:12](=[N:16][OH:17])[C:13](=O)[CH3:14].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:13]([CH3:14])=[C:12]([CH3:11])[N+:16]=2[O-:17])=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312444-MethoxybenzaldehydeHCID 63989692-Oxime 2,3-butanedione

Produkt 1

HCID 200640232-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 68.07 g of anisaldehyde, 50.5 g of 2,3-butanedione mono-oxime and 150 ml of acetic acid was saturated with hydrogen chloride gas and the mixture was allowed to stand at room temperature for 3 hours. The solid product was collected and recrystallized from methanol to give 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride, m.p. 194°-196° C. The latter was converted to the free base for use in the next reaction by treatment with sodium bicarbonate solution.

Aufarbeitung

  1. customThe solid product was collected
  2. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-b36a4cf35ab744a888817db0b69406a2
Quelldatensatz
uspto-grants-1991_03
Patentnummer
US05002960

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