alpha-Hydroxy-gamma-methylmercaptobutyric acid → 2-Hydroxy-4-(methylsulfanyl)butanamide

HRID 361289

Reaktionsgleichung

Reaktionsgleichung von HRID 361289
[OH:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3](O)=[O:4].OC(CCSC)C#[N:13]>>[OH:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3]([NH2:13])=[O:4]

Komponenten

3

Edukt 2

HCID 11427alpha-Hydroxy-gamma-methylmercaptobutyric acidHCID 87302Butanenitrile, 2-hydroxy-4-(methylthio)-2×

Produkt 1

HCID 103132202-Hydroxy-4-(methylsulfanyl)butanamide

Versuchsvorschrift

A further aspect of the present invention is directed to a process for the preparation of salts of 2-hydroxy-4-(methylthio)-butanoic acid from 2-hydroxy-4-(methylthio)-butanenitrile. 2-Hydroxy-4-(methylthio)-butanenitrile is enzymatically hydrated to form 2-hydroxy-4-(methylthio)-butaneamide, and the resulting 2-hydroxy-4-(methylthio)-butaneamide is hydrolyzed in a basic solution to form a salt of 2-hydroxy-4-(methylthio)-butanoic acid.

Quellen und Nachweise

ORD-Eintrag
ord-e32ebf6ac3594a0185c017bf9d7a80d3
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05866379

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