Ethyl 2-(piperidin-4-yl)acetate → N-4-cyanobenzoyl-beta-phenyl-alpha,alpha-dimethyl-beta-alanyl-4-piperidineacetic acid ethyl ester
Reaktionsgleichung
[C:1]([C:3]1[CH:24]=[CH:23][C:6]([C:7]([NH:9][CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]([CH3:16])([CH3:15])[C:12](O)=[O:13])=[O:8])=[CH:5][CH:4]=1)#[N:2].[NH:25]1[CH2:30][CH2:29][CH:28]([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:27][CH2:26]1>>[CH2:35]([O:34][C:32](=[O:33])[CH2:31][CH:28]1[CH2:29][CH2:30][N:25]([C:12](=[O:13])[C:11]([CH3:15])([CH3:16])[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[NH:9][C:7](=[O:8])[C:6]2[CH:23]=[CH:24][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:26][CH2:27]1)[CH3:36]Komponenten
3
Versuchsvorschrift
The same procedure as in Example 2-(6-2) was performed with N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanine (1.0 g, 3.10 mmol) using ethyl 4-piperidine acetate (1.59 g, 9.31 mmol) to yield an oil of N-4-cyanobenzoyl-β-phenyl-α,α-dimethyl-β-alanyl-4-piperidineacetic acid ethyl ester (0.96 g, 65.1%).