Ethanol → HCID 70284500, Verbindung

HRID 362266Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 362266
[Br:1][CH2:2][C:3]([C:5]1[C:6]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:7]=2[S:8][CH:9]=1)=O.[NH:15]1[CH2:19][CH2:18][NH:17][C:16]1=[S:20].C(O)C>C(O)(=O)C>[BrH:1].[Cl:14][C:12]1[CH:11]=[CH:10][C:7]2[S:8][CH:9]=[C:5]([C:3]3[N:17]4[CH2:18][CH2:19][N:15]=[C:16]4[S:20][CH:2]=3)[C:6]=2[CH:13]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 57175247HCID 57175247, Verbindung

Produkt 1

HCID 70284500HCID 70284500, VerbindungAusbeute 57,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of the crude 3-(2-bromoacetyl)-5-chlorobenzo[b]thiophen (4.2 g), 2-imidazolidinethione (1 g), ethanol (15 ml) and acetic acid (10 ml) was heated under reflux under nitrogen for 18 hours, then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ethanol (15 ml), and dried in vacuo to give 3-(5-chlorobenzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide as a white solid (2.1 g), m.p. 286°-288° C. (dec.).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux under nitrogen for 18 hours
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with ethanol (15 ml)
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-018a43fac15a4943bd2445c6946d8fdc
Quelldatensatz
uspto-grants-1999_02
Patentnummer
US05869492

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