Sodium Iodide → Iodomethyl hexanoate
Reaktionsgleichung
[C:1]([O:8][CH2:9]Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[I-].[Na+].C(OC[I:21])(=O)C(C)(C)C>CC(C)=O>[C:1]([O:8][CH2:9][I:21])(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Chloromethyl hexanoate (205 mg, 1.25 mmol) was stirred with sodium iodide (900 mg, 6.0 mmol) in 3 mL of dry acetone for 4 hours at room temperature. Work-up followed the procedure detailed in EXAMPLE 3 above for the preparation of iodomethyl pivalate. Iodomethyl hexanoate, CH3 (CH2)4COOCH2I, was obtained as a yellow oil in 78% yield. NMR values were consistent with the assigned structure.
Quellen und Nachweise
- ORD-Eintrag
- ord-f26bb85210104c488af55ec157d8b6d1
- Quelldatensatz
- uspto-grants-1995_05
- Patentnummer
- US05413996
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