Thymine → Thymine

HRID 36326

Reaktionsgleichung

Reaktionsgleichung von HRID 36326
[OH-].[CH2:2]([N+:6]([CH2:15][CH2:16][CH2:17][CH3:18])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][CH2:4][CH3:5].[NH:19]1[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]1=[O:21]>CN(C)C=O>[CH2:15]([N+:6]([CH2:2][CH2:3][CH2:4][CH3:5])([CH2:7][CH2:8][CH2:9][CH3:10])[CH2:11][CH2:12][CH2:13][CH3:14])[CH2:16][CH2:17][CH3:18].[NH:19]1[CH:27]=[C:25]([CH3:26])[C:23](=[O:24])[NH:22][C:20]1=[O:21]

Komponenten

5

Edukt 2

HCID 1135ThymineHCID 2723671Tetrabutylammonium Hydroxide

Produkt 2

HCID 1135ThymineHCID 16028Tetrabutylammonium

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1.5M Tetra(n-butyl)ammonium hydroxide (4.22 ml., 6.335 mole) was added to a suspension of thymine (0.913 g., 7.24 mole) in dimethylformamide (15 ml. ). The mixture was stirred for 10 minutes, and the dimethylformamide was removed in vacuo. Additional dimethylformamide (20 ml. ) was added to the white residue, and removed in vacuo. This process was repeated four times and the residue was dried under a vacuum (0.1 mm) at 50° C. overnight affording the tetra(n-butyl)ammonium salt of thymine.

Aufarbeitung

  1. customthe dimethylformamide was removed in vacuo
  2. additionAdditional dimethylformamide (20 ml. ) was added to the white residue
  3. customremoved in vacuo
  4. customthe residue was dried under a vacuum (0.1 mm) at 50° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-12b85e5ec8824ed7a2d19a54c001d385
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05414000

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