Water → 1,3-Di-cyclopropylmethyl-8-chloroxanthine

HRID 3635

Reaktionsgleichung

Reaktionsgleichung von HRID 3635
[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][C:11]([N+]([O-])=O)=[N:10][C:9]=3[N:8]([CH2:19][CH:20]3[CH2:22][CH2:21]3)[C:6]2=[O:7])[CH2:3][CH2:2]1.O(Cl)[Cl:24].O>CN(C)C=O>[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[NH:12][C:11]([Cl:24])=[N:10][C:9]=3[N:8]([CH2:19][CH:20]3[CH2:22][CH2:21]3)[C:6]2=[O:7])[CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 24646Chlorine monoxideHCID 98576581,3-Dicyclopropylmethyl-8-nitro xanthine

Produkt 1

HCID 98146571,3-Di-cyclopropylmethyl-8-chloroxanthine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1,3-Di-cyclopropylmethyl-8-nitro xanthine (6 g, 0,023 mol) was dissolved in dimethylformamide (20 ml) and reacted with phosporous oxychloride (14 g) for 1 hour at 120° C. The mixture was then treated with water and stirred for 1 hour at room temperature. The precipitate was filtered off, dissolved in ethyl acetate, dried over anhydrous sodium sulphate and the solvent was removed in vacuo, yield 2.5 g (40%), m.pt. 220° C.

Aufarbeitung

  1. filtrationThe precipitate was filtered off
  2. dissolutiondissolved in ethyl acetate
  3. dry with materialdried over anhydrous sodium sulphate
  4. customthe solvent was removed in vacuo, yield 2.5 g (40%), m.pt. 220° C.

Quellen und Nachweise

ORD-Eintrag
ord-5a647d1ec9cd418397bbe1ea009898ce
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05734051

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