Pyridine → Pyridazinyl carbamate

HRID 363987

Reaktionsgleichung

Reaktionsgleichung von HRID 363987
Cl[C:2]([O:4][C:5]1C=C[CH:8]=[CH:7][CH:6]=1)=[O:3].[N:11]1C=CC=C(N)[N:12]=1.[N:18]1C=CC=CN=1.N1C=CC=CC=1>C(N(CC)CC)C>[C:2](=[O:3])([O:4][C:5]1[N:11]=[N:12][CH:8]=[CH:7][CH:6]=1)[NH2:18]

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 9259PyridazineHCID 15891Phenyl chloroformateHCID 230373Aminopyridazine

Produkt 1

HCID 20239911Pyridazinyl carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

The reaction of a haloformate, such as phenyl chloroformate, and a pyridazineamine generally is carried out by combining a slight excess of haloformate with the pyridazine in an organic solvent, such as pyridine or triethylamine, and stirring the mixture for about 1 to about 24 hours at a temperature of about 0° to about 30° C. The product of the reaction, a pyridazinyl carbamate, is generally isolated by acidifying the reaction mixture, for instance by the addition of a mineral acid, such as hydrochloric acid or sulfuric acid, and collecting by filtration the precipitate which forms. The carbamate normally needs no further purification, but if desired it can be crystallized from common solvents, such as benzene, acetone, ethyl acetate, and the like.

Aufarbeitung

  1. customThe product of the reaction

Quellen und Nachweise

ORD-Eintrag
ord-492eae2209534bc4af5cb4e1d76c9009
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604127

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