1-(phenylmethyl)-N-propyl-3-pyrrolidinemethanamine → N-propyl-3-pyrrolidinemethanamine

HRID 364039Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364039
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][CH3:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[CH2:15]([NH:14][CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH2:16][CH3:17]

Komponenten

5

Edukt 2

HCID 142808851-(phenylmethyl)-N-propyl-3-pyrrolidinemethanamineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 13491799N-propyl-3-pyrrolidinemethanamineAusbeute 83,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 14.0 g (60.0 mmole) of 1-(phenylmethyl)-N-propyl-3-pyrrolidinemethanamine, 1.0 g of 20% palladium on carbon and 140 ml of methanol was shaken in an atmosphere of hydrogen at about 50 psi and room temperature for 24 hours. The catalyst was removed by filtering through Celite, the filtrate concentrated and distilled in vacuo to give 7.1 g of N-propyl-3-pyrrolidinemethanamine, bp 49°-50° C./0.25 mm.

Aufarbeitung

  1. customThe catalyst was removed
  2. filtrationby filtering through Celite
  3. concentrationthe filtrate concentrated
  4. distillationdistilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7172f5eca86e47e989170a876ccacf1e
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604401

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