N-((1-Benzylpyrrolidin-3-yl)methyl)cyclopropanamine → N-(Pyrrolidin-3-ylmethyl)cyclopropanamine

HRID 364042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364042
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH:15]3[CH2:17][CH2:16]3)[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[CH:15]1([NH:14][CH2:13][CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH2:17][CH2:16]1

Komponenten

5

Edukt 2

HCID 14280886N-((1-Benzylpyrrolidin-3-yl)methyl)cyclopropanamineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 13491801N-(Pyrrolidin-3-ylmethyl)cyclopropanamineAusbeute 76,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 13.6 g (59.0 mmol) of 1-(phenylmethyl)-N-cyclopropyl-3-pyrrolidinemethanamine, 0.5 g of 20% palladium on carbon and 140 ml of methanol was shaken in an atmosphere of hydrogen at about 50 psi and room temperature for 24 hours. The catalyst was removed by filtering through Celite, the filtrate concentrated and distilled in vacuo to give 6.3 g of N-cyclopropyl-3-pyrrolidinemethanamine, bp 88°-90° /13 mm.

Aufarbeitung

  1. customThe catalyst was removed
  2. filtrationby filtering through Celite
  3. concentrationthe filtrate concentrated
  4. distillationdistilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-77ea3d42f14347a5b8e05b00e6d3254a
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604401

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