N-((1-Benzylpyrrolidin-3-yl)methyl)propan-2-amine → N-(Pyrrolidin-3-ylmethyl)propan-2-amine

HRID 364045Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364045
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH:15]([CH3:17])[CH3:16])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[CH3:16][CH:15]([NH:14][CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]

Komponenten

5

Edukt 2

HCID 14280887N-((1-Benzylpyrrolidin-3-yl)methyl)propan-2-amineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 13491802N-(Pyrrolidin-3-ylmethyl)propan-2-amineAusbeute 76,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 13.4 g (58.0 mmol) of 1-phenylmethyl-N-(2-propyl)-3-pyrrolidinemethanamine, 1.0 g of 20% palladium on carbon and 130 ml of methanol was shaken in an atmosphere of hydrogen at about 50 psi and room temperature for 24 hours. The catalyst was removed by filtration through Celite; the filtrate concentrated and distilled in vacuo to give 6.3 g of N-(2-propyl)-3-pyrrolidinemethanamine, bp 58°-60° C./3.5 mm.

Aufarbeitung

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe filtrate concentrated
  3. distillationdistilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7bbc8b96be0d4768a278540ac6403506
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604401

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