2-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanol → 2-[(3-Pyrrolidinylmethyl)amino]ethanol

HRID 364048

Reaktionsgleichung

Reaktionsgleichung von HRID 364048
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1

Komponenten

5

Edukt 2

HCID 142808882-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 134918032-[(3-Pyrrolidinylmethyl)amino]ethanolAusbeute 57,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 32.32 g of 2-[[[1-(phenylmethyl)3-pyrrolidinyl]methyl]amino]ethanol, 330 ml of methanol and 3 g of 20% palladium on charcoal was shaken in an atmosphere of hydrogen at about 50 psi and at room temperature for 18 hours. The solvents were then removed at reduced pressure. The residue was distilled under vacuum (bp 129°-131° C. 1.5 mm Hg) to give 11.43 g of 2-[(3-pyrrolidinyl methyl)amino] ethanol.

Aufarbeitung

  1. customThe solvents were then removed at reduced pressure
  2. distillationThe residue was distilled under vacuum (bp 129°-131° C. 1.5 mm Hg)

Quellen und Nachweise

ORD-Eintrag
ord-999c7c4945a147c4b5b1ed4dd7eaeba5
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604401

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