Methyl isothiocyanate → 1-Methyl-3-trifluoromethanesulphonylthiourea

HRID 364275

Reaktionsgleichung

Reaktionsgleichung von HRID 364275
[CH3:1][N:2]=[C:3]=[S:4].[F:5][C:6]([F:12])([F:11])[S:7]([NH2:10])(=[O:9])=[O:8].[OH-].[Na+]>CC(C)=O.O>[CH3:1][NH:2][C:3]([NH:10][S:7]([C:6]([F:12])([F:11])[F:5])(=[O:9])=[O:8])=[S:4]

Komponenten

6

Edukt 3

HCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 79001Trifluoromethylsulfonamide

Produkt 1

HCID 212988821-Methyl-3-trifluoromethanesulphonylthioureaAusbeute 42,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of methylisothiocyanate (0.21 g.) in acetone (10 ml.) was added to a solution of trifluoromethanesulphonamide (0.45 g.) and sodium hydroxide (0.12 g.) in water (5 ml.), the mixture stirred at 60° for 18 hours and then evaporated to dryness. The residue was dissolved in water and the solution washed with ethyl acetate and then adjusted to pH 1 with concentrated hydrochloric acid. The mixture was treated with charcoal and filtered and the filtrate extracted with ethyl acetate. The combined ethyl acetate extracts were dried and evaporated to dryness and the residue recrystallised from petroleum ether (b.p. 60°-80°) to give 1-methyl-3-trifluoromethanesulphonylthiourea (0.27 g.), m.p. 88°-90°.

Aufarbeitung

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in water
  3. washthe solution washed with ethyl acetate
  4. additionThe mixture was treated with charcoal
  5. filtrationfiltered
  6. extractionthe filtrate extracted with ethyl acetate
  7. dry with materialThe combined ethyl acetate extracts were dried
  8. customevaporated to dryness
  9. customthe residue recrystallised from petroleum ether (b.p. 60°-80°)

Quellen und Nachweise

ORD-Eintrag
ord-9af2fa82a3d64c4b9413c5ffa41d9449
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04604465

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