Acetone → N-methyl-2-(2-methylphenyl)-2-oxoacetamide

HRID 36428

Reaktionsgleichung

Reaktionsgleichung von HRID 36428
[CH3:1][N+:2]#[C-:3].[CH3:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](Cl)=[O:8].Cl.CC(C)=[O:17]>O>[CH3:3][NH:2][C:1](=[O:17])[C:7]([C:6]1[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=1[CH3:4])=[O:8]

Komponenten

6

Edukt 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 11646Methyl isocyanideHCID 702762-Methylbenzoyl chloride

Produkt 1

HCID 15239356N-methyl-2-(2-methylphenyl)-2-oxoacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

Aufarbeitung

  1. stirringthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
  2. extractionThe mixture was extracted with methylene chloride
  3. washwashed with water
  4. customdried
  5. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-33cb00ace74546bf936022e8d0659d2b
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05414122

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