Hydrochloric Acid → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine

HRID 364735Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364735
[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)[CH3:2].Cl>C(O)C.O.[Pt]=O>[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1)[CH3:2]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

Produkt 1

HCID 134731494-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidineAusbeute 70,6 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

The solution of 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.1 g, 0.0054M) in ethanol (15 ml) and water (15 ml) was added con.HCl (3 ml) and platinum oxide (0.2 g). The mixture was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness in vacuo. The residue was dissolved in methanol (25 ml) and sodium methoxide (0.011M) was added and filtered. The filtrate was stripped to dryness and distilled at about 150° to about 175° C./0.2 mm Hg to yield 4-[2-(1-ethyl-4,5-dihydro-imdazol-2-yl)ethyl]piperidine as an oil (0.8 g, 70% yield).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. dissolutionThe residue was dissolved in methanol (25 ml)
  3. additionsodium methoxide (0.011M) was added
  4. filtrationfiltered
  5. distillationdistilled at about 150° to about 175° C./0.2 mm Hg

Quellen und Nachweise

ORD-Eintrag
ord-0d3666a787654767a2885baddfed68b6
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04605744

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