Water → HCID 13292600, Verbindung

HRID 364997Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 364997
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][OH:10])[CH:4]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].O>O1CCCC1>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH2:9][OH:10])[CH:4]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 132925992-(Hydroxymethyl)pyridine-4-carbonitrileHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 13292600HCID 13292600, VerbindungAusbeute 54,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

A solution of 4-cyano-2-hydroxymethylpyridine (0.5 g) in tetrahydrofuran (25 ml) was added dropwise over 20 minutes to a stirred mixture of lithium aluminium hydride (0.25 g) in tetrahydrofuran (30 ml) and the mixture was stirred at room temperature for 2 hours. Wet tetrahydrofuran followed by 0.35 ml of 16% w/w aqueous sodium hydroxide and water were added and the mixture was filtered. The filtrate was evaporated to give crude 4-aminomethyl-2-hydroxymethylpyridine (0.28 g).

Aufarbeitung

  1. additionwere added
  2. filtrationthe mixture was filtered
  3. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-e89e369c398640a0beddf2a8300ce4a8
Quelldatensatz
uspto-grants-1986_08
Patentnummer
US04607107

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