Methanol → Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride

HRID 365437

Reaktionsgleichung

Reaktionsgleichung von HRID 365437
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[C:3]([C:10]([OH:12])=[O:11])[CH:2]=1.S(Cl)([Cl:15])=O.[CH3:17]O>>[ClH:15].[CH3:17][O:8][C:7]([C:5]1[CH:6]=[N:1][CH:2]=[C:3]([C:10]([OH:12])=[O:11])[CH:4]=1)=[O:9]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 103663,5-Pyridinedicarboxylic acidHCID 24386Thionyl Chloride

Produkt 1

HCID 70274642Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride

Versuchsvorschrift

Pyridine-3,5-dicarboxylic acid (5.00 g, 29.9 mmol) was stirred in CH3OH (100 mL), cooled in an ice bath, and treated dropwise with thionyl chloride (17.45 mL, 239.2 mmol). After 0.5 hr, the reaction mixture was refluxed for 48 hrs. Concentration to dryness gave the title compound as an off-white solid.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. temperaturethe reaction mixture was refluxed for 48 hrs
  3. concentrationConcentration to dryness

Quellen und Nachweise

ORD-Eintrag
ord-1b62a4aa5e3545ef8cc070eb914f7418
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06127366

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