Methanol → (3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

HRID 365958Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 365958
C([O:4][C:5]1[CH:25]=[CH:24][C:23]([Br:26])=[C:22]([CH3:27])[C:6]=1[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>O>[Br:26][C:23]1[CH:24]=[CH:25][C:5]([OH:4])=[C:6]([C:22]=1[CH3:27])[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 109062512-Acetoxy-5-bromo-6,6'-dimethyl-2', 3', 4'-trimethoxy-benzophenone

Produkt 1

HCID 10938097(3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A mixture of 1D (0.7 g, 1.6 mmol), potassium carbonate (0.7 g), methanol (10 ml) and water (5 ml) is stirred at room temperature for 20 hours. The reaction mixture is poured into water and extracted with diisopropylether. The organic phase is separated and concentrated. The pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

Aufarbeitung

  1. extractionextracted with diisopropylether
  2. customThe organic phase is separated
  3. concentrationconcentrated
  4. customThe pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

Quellen und Nachweise

ORD-Eintrag
ord-ee76843728674c7b8b3741362ba4a957
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06127570

Notizen zur Reaktion

Wird geladen…