4-Bromoaniline → SMR000102306
Reaktionsgleichung
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.O=[C:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:15]#[N:16].[Cl-].[Ca+2].[Cl-]>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2[C:15]#[N:16])=[CH:4][CH:3]=1Komponenten
4
Versuchsvorschrift
4-Bromo-aniline (Aldrich Chemicals) (3.5 g, 20 mmol), cyano-ketone (Example 11) (2.2 g, 20 mmol), calcium chloride (2.5 g, 23 mmol) and T.H.F. (30 ml) were heated under reflux for 7 hours. After being allowed to cool, the mixture was filtered and the solvent evaporated. Kugelrohr distillation (150° C., 0.07 mmHg) gave the product as a brown-grey powder.
Aufarbeitung
- temperature(30 ml) were heated
- temperatureunder reflux for 7 hours
- temperatureto cool
- filtrationthe mixture was filtered
- customthe solvent evaporated
- distillationKugelrohr distillation (150° C., 0.07 mmHg)
Quellen und Nachweise
- ORD-Eintrag
- ord-d147e446509947a89d08c958616866ce
- Quelldatensatz
- uspto-grants-2000_10
- Patentnummer
- US06130228
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