Acetic Acid → HCID 22448959, Verbindung

HRID 366456Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 366456
[OH:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:14](O)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:14]([O:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:16])[CH3:15]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 99422906-Hydroxy-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Produkt 1

HCID 22448959HCID 22448959, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A suspension of 1,3,4,5-tetrahydro-6-hydroxy-2H-1-benzazepin-2-one (500 mg, 2.82 mmol) in 2.5 mL each of pyridine and acetic acid was stirred at room temperature. Excess reagents were removed under reduced pressure and the residue was triturated with CH2Cl2 to give 540 mg (87%) of 1,3,4,5-tetrahydro-6-acetoxy-2H-1-benzazepin-2-one; MS 219.

Aufarbeitung

  1. customExcess reagents were removed under reduced pressure
  2. customthe residue was triturated with CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-70c2dc89be7249f8a3520f32da86a2e0
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06130217

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