tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate → rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate

HRID 36654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 36654
C([N:8]1[CH2:12][C@@H:11]([O:13][CH3:14])[C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:14][O:13][C@@H:11]1[CH2:12][NH:8][CH2:9][C@H:10]1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21]

Komponenten

4

Edukt 1

HCID 15069969tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate

Produkt 1

HCID 15069971rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

6.7 g (22 mmol) of tert.-butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3-yl)carbamate are hydrogenated in 150 ml of methanol on 2 g of palladium-on-active charcoal (10% of Pd) under 100 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Aufarbeitung

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-94462c4fdb6a43548a178c056ea9d5a2
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05416096

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