Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate → 6-Trifluoromethyloxindole

HRID 366560

Reaktionsgleichung

Reaktionsgleichung von HRID 366560
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([O:17]C)=O)([O-])=O>[Pd]>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:9]=[C:4]2[C:5]([CH2:14][C:15](=[O:17])[NH:1]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 83569Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

Produkt 1

HCID 6084876-Trifluoromethyloxindole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Methyl 2-nitro-4-trifluoromethylphenylacetate (26 mg) was hydrogenated over 10% palladium on carbon and then heated at 100° C. for 3 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-582a4b27dfec42329964f2b3ebc081f5
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06130238

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