Ethyl Acetoacetate → Ethyl 3-Hydroxybutyrate

HRID 366988

Reaktionsgleichung

Reaktionsgleichung von HRID 366988
[O:1]=[C:2]([CH3:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>CO.O>[OH:1][CH:2]([CH3:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]

Komponenten

3

Edukt 1

HCID 8868Ethyl Acetoacetate

Produkt 1

HCID 62572Ethyl 3-Hydroxybutyrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

The same procedure of Example 5 is repeated with the only differences that 1.95 g of ethyl 3-oxo-butyrate were weighed and dissolved in MeOH/H2O 19/1 (v/v) and the catalyst of Example 15 was utilized. At the end of the reaction, the ethyl 3-hydroxybutyrate resulted to be equal to 91%, while the ethyl 3-dimetoxybutyrate resulted equal to 9%. The stereoinduction was >99% in favour of the antipode (S).

Aufarbeitung

  1. customAt the end of the reaction

Quellen und Nachweise

ORD-Eintrag
ord-06436ccc24a740108351f3988fd3e4b7
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133191

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