Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 367015Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 367015
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C)C=O>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

Produkt 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chlorideAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid and 84 g of oxalyl chloride are stirred at room temperature for 5 hours in 930 ml of dry methylene chloride with addition of a few drops of dimethylformamide. The methylene chloride is then stripped off and the residue is distilled in vacuo. 117.6 g of 3-cyano-2,4,5-trifluoro-benzoyl chloride are obtained as a yellow oil.

Aufarbeitung

  1. distillationthe residue is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c305de2533e74749a9a665a3cad0b132
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133260

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