Acetic Acid → HCID 70137322, Verbindung

Reaktionsgleichung

C(OC([NH:11][C@H:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][C:24]([N:26]([CH3:28])[CH3:27])=[O:25])=[CH:17][CH:18]=2)[CH2:13]1)=O)C1C=CC=CC=1.[H][H].[C:31]([OH:34])(=[O:33])[CH3:32]>[C].[Pd]>[C:31]([OH:34])(=[O:33])[CH3:32].[NH2:11][C@H:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][C:24]([N:26]([CH3:28])[CH3:27])=[O:25])=[CH:17][CH:18]=2)[CH2:13]1

Komponenten

Versuchsvorschrift

(S)-2 -[2-(Benzyloxycarbonylamino)-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide (100 mg) and 20 mg of 10% palladium-carbon were suspended in 5 ml of acetic acid and the suspension was stirred at room temperature for 3 hours in an atmosphere of hydrogen. The catalyst was removed by filtration, the filtrate was concentrated under reduced pressure, and the residue was recrystallized from ethanoldiethyl ether to give 72 mg of (S)-2-(2-amino-1,2,3,4-tetrahydronaphthalen-7-yloxy)-N,N-dimethylacetamide acetate having a melting point of 135 to 142° C.