5-Bromoindole → 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

HRID 367369Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 367369
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1.N1CCCC1>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 249055-BromoindoleHCID 31268PyrrolidineHCID 740491-Methyl-4-piperidone

Produkt 1

HCID 149732085-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indoleAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5-Bromo-1H-indole (4.31 g, 22 mmol), 1-methyl-4-piperidone (2.46 mL, 20 mmol) and pyrrolidine (17 mL, 200 mmol) were mixed in ethanol (30 mL) and refluxed for 72 hours. The mixture was cooled to room temperature and the resulting solid, collected by filtration, washed with methanol and dried to provide the title compound as a white solid (4.40 g, 76%). mp>230° C., dec.

Aufarbeitung

  1. temperaturerefluxed for 72 hours
  2. filtrationthe resulting solid, collected by filtration
  3. washwashed with methanol
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b7cd3a6acffc4baeb09b2ac3fbb58cd8
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133287

Notizen zur Reaktion

Wird geladen…