Acetonitrile → 4-(t-Butylamino)-2,3,5,6-tetrafluoropyridine

HRID 368418

Reaktionsgleichung

Reaktionsgleichung von HRID 368418
C(#N)C.[F:4][C:5]1[N:10]=[C:9]([F:11])[C:8]([F:12])=[C:7](F)[C:6]=1[F:14].[C:15]([NH2:19])([CH3:18])([CH3:17])[CH3:16]>C(Cl)(Cl)Cl>[C:15]([NH:19][C:7]1[C:8]([F:12])=[C:9]([F:11])[N:10]=[C:5]([F:4])[C:6]=1[F:14])([CH3:18])([CH3:17])[CH3:16]

Komponenten

5

Edukt 3

HCID 6342AcetonitrileHCID 6385Tert-ButylamineHCID 69690Pentafluoropyridine

Produkt 1

HCID 221211594-(t-Butylamino)-2,3,5,6-tetrafluoropyridineAusbeute 71,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To 100 ml of acetonitrile was added 24.5 g of pentafluoropyridine, and the mixture was stirred in an ice bath simultaneously with the dropwise addition of 30 g of t-butylamine. When the mixture warmed to room temperature, 150 ml of chloroform was added, and the mixture was washed twice with 800 ml of distilled water. The chloroform layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 23 g of the title compound as a pale yellow oil.

Aufarbeitung

  1. washthe mixture was washed twice with 800 ml of distilled water
  2. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c491565e5fa549ff8464593fe08b775f
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133284

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