Hydrochloric Acid → 1-(4-Amino-5-fluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

HRID 368463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 368463
Cl.[NH2:2][C:3]1[C:8]([F:9])=[CH:7][N:6]=[C:5]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([F:21])[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([O:26]CC)=[O:25])=[CH:11]2)[CH:4]=1>C(O)(=O)C>[NH2:2][C:3]1[C:8]([F:9])=[CH:7][N:6]=[C:5]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([F:21])[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:4]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22121193Ethyl 1-(4-amino-5-fluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Produkt 1

HCID 221211881-(4-Amino-5-fluoropyridin-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidAusbeute 95,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To 400 mg of the mixed solution (1:1) of 4N hydrochloric acid and acetic acid was added 35 mg of ethyl 1-(4-amino-5-fluoropyridine-2-yl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate, and the mixture was heated under reflux with stirring for 3 hours and allowed to cool. The precipitate was collected by filtration, and washed with distilled water, ethanol and diisopropylether successively to obtain 31 mg of the title compound as a pale yellow powder.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux
  3. temperatureto cool
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with distilled water, ethanol and diisopropylether successively

Quellen und Nachweise

ORD-Eintrag
ord-c690c3e6209346e188e4d6ad936ad798
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133284

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