2-chloro-N-ethylbenzamide → n-Ethyl-2-chloro-6-(ethenyldimethylsilyl)benzamide
Reaktionsgleichung
[CH2:1]([NH:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2].[CH:13]([Si:15](Cl)([CH3:17])[CH3:16])=[CH2:14]>>[CH2:1]([NH:3][C:4](=[O:12])[C:5]1[C:10]([Si:15]([CH:13]=[CH2:14])([CH3:17])[CH3:16])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:11])[CH3:2]Komponenten
3
Versuchsvorschrift
The title compound was prepared from the compound of Example f and 1.5 eq vinyldimethylsilyl chloride according to General Method C. Purification by HPLC with 1:4 ethyl acetate/hexanes gave 630 mg of the desired product as a white solid, a 9% yield. m.p. 86-89° C.
Aufarbeitung
- customPurification by HPLC with 1:4 ethyl acetate/hexanes
Quellen und Nachweise
- ORD-Eintrag
- ord-e516eaac738c431c89d10dde00a955ba
- Quelldatensatz
- uspto-grants-2000_10
- Patentnummer
- US06133252
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