Water → Isonicotinamide

HRID 368809

Reaktionsgleichung

Reaktionsgleichung von HRID 368809
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)#[N:2].[OH2:9]>O1CCCC1>[N:6]1[CH:7]=[CH:8][C:3]([C:1]([NH2:2])=[O:9])=[CH:4][CH:5]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 75064-Cyanopyridine

Produkt 1

HCID 15074IsonicotinamideAusbeute 91,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

(0.0051 g, 0.0119 mmol) of the platinum complex, prepared as in Example 1, was stirred with 4-cyanopyridine (2.0 g, 0.019 mol) and 0.75 ml (0.042 mol) of water and 10 ml tetrahydrofuran and the mixture heated under reflux for 4 hours. After cooling the liquids were removed using a rotary evaporator to give pyridine 4-carboxamide (2.12 g) corresponding to 90% yield.

Aufarbeitung

  1. custom(0.0051 g, 0.0119 mmol) of the platinum complex, prepared as in Example 1
  2. temperaturethe mixture heated
  3. temperatureunder reflux for 4 hours
  4. temperatureAfter cooling the liquids
  5. customwere removed
  6. customa rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-abe4130096944c17b8c663f5db1a3233
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06133478

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