Hydrochloric Acid → 2-Methylbenzenesulfonic acid

HRID 370007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 370007
N#[C-].N[C:4]1[CH:12]=[CH:11][C:7]([C:8](N)=N)=[CH:6][CH:5]=1.Cl.[S:14](=O)(=[O:17])([OH:16])[OH:15].B(F)(F)F.CCOCC>O.C(O)(C)C.O1CCCC1.O1CCOCC1.C(O)C.CO>[C:7]1([CH3:8])[C:6]([S:14]([OH:17])(=[O:16])=[O:15])=[CH:5][CH:4]=[CH:12][CH:11]=1

Komponenten

12

Edukt 5

HCID 313Hydrochloric AcidHCID 1118Sulfuric AcidHCID 1725p-AminobenzamidineHCID 5975CyanideHCID 8000Boron trifluoride etherate

Produkt 1

HCID 69252-Methylbenzenesulfonic acid

Reagenzien, Katalysatoren, Lösungsmittel 6

HCID 702EthanolLösungsmittelHCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×HCID 3776IsopropanolLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel2×HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The reaction of a substituted benzaldehyde of the formula II, an isonitrile of the formula RNC and a 4-aminobenzamidine of the formula III is advantageously carried out in a solvent (e.g. methanol, isopropanol, ethanol, dioxane, or tetrahydrofuran), or in a solvent mixture (e.g. tetrahydrofuran and water or isopropanol and water), advantageously by using an inorganic acid (e.g. hydrochloric acid, sulphuric acid or boron trifluoride etherate), or an organic acid (e.g. toluenesulphonic acid), or in acidic ion exchanger (e.g. Amberlyst K10) as catalyst, at a temperature between 0° C. and 100° C., giving compounds of the formula I. The reaction of a substituted aldehyde of the formula II, of an isonitrile of the formula R1NC and 4-aminobenzonitrile under similar reaction conditions leads to compounds of the formula IV in which Q is hydrogen.

Quellen und Nachweise

ORD-Eintrag
ord-ad53b657205646afaa67ccde8672ba4f
Quelldatensatz
uspto-grants-2000_10
Patentnummer
US06140353

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