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Water → (E)-1,2-difluoro-1-(4-propylphenyl)ethylene

HRID 37023
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 37023
[F:1]/[C:2](/[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH3:17])=[CH:11][CH:10]=1)=[C:3](/[F:8])\[Si](C)(C)C.[F-].[K+].O>C(#N)C>[F:1]/[C:2](/[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH3:17])=[CH:11][CH:10]=1)=[CH:3]/[F:8]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 962Water2×HCID 522689Potassium FluorideHCID 19934212HCID 19934212, Verbindung

Produkt 1

HCID 67780891(E)-1,2-difluoro-1-(4-propylphenyl)ethyleneAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Then, 19.1 g (0.075 mol) of the obtained (Z)-1,2-difluoro-1-(4-n-propylphenyl)-2-trimethylsilylethylene was dissolved in 50 ml of acetonitrile, and then 8.70 g (0.15 mol) of potassium fluoride and 4.05 g (0.225 mol) of water were added thereto. The mixture was reacted for one hour at 70° C. The reaction mixture was cooled, and then 200 ml of water was added thereto. The mixture was extracted with methylene chloride. The organic layer was washed with a saturated sodium chloride aqueous solution and dried over CaCl2. After filtration, the solvent and low boiling substances were distilled off, and the residue was further distilled under reduced pressure to obtain 11.3 g (yield: 83%) of (E)-1,2-difluoro-1-(4-propylphenyl)ethylene.

Aufarbeitung

  1. customThe mixture was reacted for one hour at 70° C
  2. temperatureThe reaction mixture was cooled
  3. extractionThe mixture was extracted with methylene chloride
  4. washThe organic layer was washed with a saturated sodium chloride aqueous solution
  5. dry with materialdried over CaCl2
  6. filtrationAfter filtration
  7. distillationthe solvent and low boiling substances were distilled off
  8. distillationthe residue was further distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6abe231905dc4727a9662231775d9c62
Quelldatensatz
uspto-grants-1995_05
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05419851

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