Boron trifluoride etherate → 2,3,5,6-Tetrafluorophenyl trifluoroacetate

HRID 37028

Reaktionsgleichung

Reaktionsgleichung von HRID 37028
F[C:2]([F:13])(F)[C:3]([O:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8])=O.[F:14][C:15]1[C:20]([F:21])=CC(F)=[C:17]([F:23])[C:16]=1O.B(F)(F)F.CCOCC>>[F:10][C:7]([F:8])([F:9])[C:6]([O:5][C:3]1[C:2]([F:13])=[C:17]([F:23])[CH:16]=[C:15]([F:14])[C:20]=1[F:21])=[O:11]

Komponenten

4

Edukt 3

HCID 8000Boron trifluoride etherateHCID 9845Trifluoroacetic anhydrideHCID 698582,3,5,6-Tetrafluorophenol

Produkt 1

HCID 153342582,3,5,6-Tetrafluorophenyl trifluoroacetateAusbeute 75 %

Versuchsvorschrift

Trifluoroacetic anhydride (28 mL, 0.2 mol) was added dropwise with stirring to 27.1 g (0,163 mol) of 2,3,5,6tetrafluorophenol. Boron trifluoride etherate (0.2 mL) was added and the mixture was refluxed overnight. The residual solution was distilled at atmospheric pressure to remove trifluoroacetic anhydride and trifluoroacetic acid. The desired product 18 (32.2 g; 75% yield) was collected at 45° C. (18mm) as a colorless liquid:

Aufarbeitung

  1. temperaturethe mixture was refluxed overnight
  2. distillationThe residual solution was distilled at atmospheric pressure
  3. customto remove trifluoroacetic anhydride and trifluoroacetic acid

Quellen und Nachweise

ORD-Eintrag
ord-0f9b25f93fa74c2990bd28e8b3c03f57
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05419966

Verknüpfte Notizen

Wird geladen…