Pyridinium chloride → 6,7-Dichloro-1-benzothiophene-5-ol
Reaktionsgleichung
[Cl:1][C:2]1[C:3]([O:12]C)=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[C:10]=1[Cl:11].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:3]([OH:12])=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[C:10]=1[Cl:11]Komponenten
3
Versuchsvorschrift
A mixture of 45 g of 6,7-dichloro-5-methoxybenzo[b]thiophene and 5 g of pyridine hydrochloride is stirred at 180° for 1 hour. The mixture is cooled, triturated with water and extracted thrice with ether. The ether solution is washed with water, dried and concentrated to give 0.42 g of 6,7-dichloro-5-hydroxybenzo[b]thiophene as a tan-colored solid. Recrystallization from acetone-hexane gives prisms, mp 97°-98°.
Aufarbeitung
- temperatureThe mixture is cooled
- customtriturated with water
- extractionextracted thrice with ether
- washThe ether solution is washed with water
- customdried
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-0d9f1e079729447ea026f3a9f6b782e8
- Quelldatensatz
- uspto-grants-1985_07
- Patentnummer
- US04528399
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