Pyridinium chloride → 6,7-Dichloro-1-benzothiophene-5-ol

HRID 370939

Reaktionsgleichung

Reaktionsgleichung von HRID 370939
[Cl:1][C:2]1[C:3]([O:12]C)=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[C:10]=1[Cl:11].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[C:3]([OH:12])=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[C:10]=1[Cl:11]

Komponenten

3

Edukt 2

HCID 10176127Pyridinium chlorideHCID 132899966,7-Dichloro-5-methoxybenzo[b]thiophene

Produkt 1

HCID 132899976,7-Dichloro-1-benzothiophene-5-olAusbeute 1 %

Versuchsvorschrift

A mixture of 45 g of 6,7-dichloro-5-methoxybenzo[b]thiophene and 5 g of pyridine hydrochloride is stirred at 180° for 1 hour. The mixture is cooled, triturated with water and extracted thrice with ether. The ether solution is washed with water, dried and concentrated to give 0.42 g of 6,7-dichloro-5-hydroxybenzo[b]thiophene as a tan-colored solid. Recrystallization from acetone-hexane gives prisms, mp 97°-98°.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. customtriturated with water
  3. extractionextracted thrice with ether
  4. washThe ether solution is washed with water
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0d9f1e079729447ea026f3a9f6b782e8
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04528399

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