Water → 4-Chloro-2-ethyl-6-{[4-(propan-2-yl)phenyl]methyl}phenol

HRID 371523Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 371523
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1.[CH:11]([C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1)([CH3:13])[CH3:12].O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:18][C:17]2[CH:20]=[CH:21][C:14]([CH:11]([CH3:13])[CH3:12])=[CH:15][CH:16]=2)[C:5]([OH:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 293574-Chloro-2-EthylphenolHCID 749164-Isopropylbenzyl chloride

Produkt 1

HCID 233194194-Chloro-2-ethyl-6-{[4-(propan-2-yl)phenyl]methyl}phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

117.5 g (0.75 mol) 4-chloro-2-ethylphenol are dissolved with 42.25 g (0.25 mol) 4-isopropylbenzylchloride in 200 ml chloroform. 22.5 g water-free zinc chloride are added thereto for the alkylation reaction. Already at 30° C. a powerful reaction takes place. The entire mixture is after-stirred 5-6 h at 60° C. for completion of the alkylation. After a cooling it is subsequently washed three times each with 200 ml water, and then dried across sodium sulfate, after which the solvent chloroform is driven off.

Aufarbeitung

  1. customfor the alkylation reaction
  2. customAlready at 30° C. a powerful reaction
  3. washAfter a cooling it is subsequently washed three times each with 200 ml water
  4. dry with materialdried across sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-fd94c07d2e76497d84a4d35ea1dcde1e
Quelldatensatz
uspto-grants-1985_07
Patentnummer
US04532367

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