Trifluoroacetyl chloride → 1-hydroxy-5,6-dichloro-2-trifluoromethyl-1H-imidazo(4,5-b)-pyridine
Reaktionsgleichung
ClC1C=C([N+]([O-])=O)C(N)=NC=1Cl.FC(F)(F)C(Cl)=O.[Cl:20][C:21]1[CH:22]=[C:23]([N+:35]([O-:37])=O)[C:24]([NH:28][C:29](=O)[C:30]([F:33])([F:32])[F:31])=[N:25][C:26]=1[Cl:27]>>[OH:37][N:35]1[C:23]2[C:24](=[N:25][C:26]([Cl:27])=[C:21]([Cl:20])[CH:22]=2)[N:28]=[C:29]1[C:30]([F:33])([F:32])[F:31]Komponenten
4
Versuchsvorschrift
In like procedures, 5,6-dichloro-2-amino-3-nitropyridine was reacted with trifluoroacetyl chloride and the resulting 5,6-dichloro-2-trifluoroacetamido-3-nitropyridine was hydrogenated to obtain 1-hydroxy-5,6-dichloro-2-trifluoromethyl-1H-imidazo(4,5-b)-pyridine, m.p. 207°-208° C.