3-Methylbenzoic acid → 3-Methylbenzoyl chloride

HRID 37185

Reaktionsgleichung

Reaktionsgleichung von HRID 37185
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](O)=[O:8])[CH:2]=1.C(Cl)(=O)C([Cl:14])=O>C1C=CC=CC=1.CN(C=O)C>[CH3:10][C:1]1[CH:2]=[C:3]([CH:4]=[CH:5][CH:6]=1)[C:7]([Cl:14])=[O:8]

Komponenten

5

Edukt 2

HCID 74183-Methylbenzoic acidHCID 65578Oxalyl chloride

Produkt 1

HCID 743753-Methylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

Meanwhile, the 3-methylbenzoyl chloride acylating agent was prepared by suspending 3.016 g (22.0 mmol) of m-toluic acid in 100 ml benzene. To this solution was added 2.0 equiv. (3.84 ml) of oxalyl chloride, dropwise via a pressure-equalizing dropping funnel at O° C. DMF (2-3 drops) was added to the reaction mixture catalytically and the ice bath was removed. The progress of the reaction was monitored via infrared spectroscopy. The solvent was removed by rotary vacuum evaporation and the residual oil was pumped down under high vacuum overnight.

Aufarbeitung

  1. customthe ice bath was removed
  2. customThe solvent was removed by rotary vacuum evaporation
  3. customwas pumped down under high vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-327c30f17ea74844a93444c148790f2c
Quelldatensatz
uspto-grants-1995_05
Patentnummer
US05420134

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